These results are consistent with, and expand, the findings from previous studies that showed the improvement in whole-body insulin sensitivity, assessed by using an oral glucose tolerance test, insulin suppression test, or the glucose infusion rate during a hyperinsulinemic-euglycemic clamp procedure, after moderate (6%–14%) weight loss was blunted in people with obesity who were “insulin-sensitive” compared with those who were “insulin-resistant” (24–28). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.