In addition, glycine and serine, which increased more in Responders than Non-responders, are associated with increased insulin sensitivity, and dimethylguanidino valeric acid, tyrosine, and uridine, which decreased more in Responders than Non-responders, are associated with insulin resistance, hepatic steatosis, and increased risk of developing type 2 diabetes (38–43). The gene discussed is INS; the disease is type 2 diabetes mellitus.