Responders and Non-responders were identified as participants within the top (>75% increase) and bottom (<5% increase) quartiles of the increase in insulin-stimulated glucose disposal rate during a hyperinsulinemic-euglycemic clamp procedure among 43 women with class II and class III obesity (body mass index ≥35 kg/m2). Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.