INS and obesity due to melanocortin 4 receptor deficiency: Baseline insulin-stimulated glucose disposal, and additional markers of metabolic health associated with insulin action (hepatic insulin sensitivity index, plasma glucose and insulin concentrations, and intrahepatic triglyceride content; refs. (18, 19) in Non-responders were similar to values we have previously found in people who were lean and healthy and those with metabolically healthy obesity (18–23).