To address whether tumor antigen reactive T cells can trigger TSPO expression, we loaded HLA-A2+ BTIC lines BTIC13 (mesenchymal) and BTIC129 (proneural) with an HLA-A2-restricted peptide derived from the Influenza matrix protein M1 (flu-peptide) as a model tumor antigen (influenza matrix protein) and co-cultured them with antigen specific cytotoxic CD8+ T cells (FluTC) which we generated from HLA-A2 + healthy donor PBMCs by repetitive antigen stimulation. The gene discussed is CD8A; the disease is neoplasm.