HIF1A and intervertebral disk degenerative disorder: The effects of HIF-1α on proliferation, apoptosis, migration, and NPC-like differentiation of ADSCs were investigated in vitro. In addition, the changes of ER stress of ADSCs under hypoxic conditions were observed, and their relationships with HIF-1α were preliminarily verified. We expect that this study will provide more effective therapeutic strategies and new targets for the treatment of IDD by stem cell transplantation.