Figure 7D indicated that the signaling pathways at progression in R/R-MM included BAFF, CLEC, MIF, ITGB2, CD99, MHC-I, CXCL, PARs, CCL, LCK, RESISTIN, APRIL, CSF, IL4 and IL2. The gene discussed is ITGB2; the disease is Miyoshi myopathy.