Previous studies indicated that APRIL expressed by monocytes/macrophages is a ligand of BCMA expressed by multiple myeloma cells, which can rescue interleukin 6 (IL-6)–dependent MM cell lines from apoptosis following IL-6 deprivation, stimulate MM cell growth via cyclin D-dependent G1/S cell cycle progression and induced immunosuppression in the bone marrow microenvironment [75–79]. This evidence concerns the gene TNFRSF17 and plasma cell myeloma.