Immediate pathogenic efficacy is dependent on viral tropism and replication, and there have been a few reports of direct infection of HSPCs with altered BM output. For example, SARS-CoV-2 may, on the one hand, directly infect the pool of HSPCs, and other pathological triggers of the Nlrp3 inflammasome may result in cytokine storm and pyroptosis of these cells [59]. This evidence concerns the gene NLRP3 and infection.