Two landmark randomized controlled trials (RCTs) (LUX-Lung 3 and Lux-Lung 6) demonstrated a significant improvement in objective response rate (ORR) and progression-free survival (PFS) with afatinib compared with platinum-based chemotherapy as first-line treatment in EGFR-mutated metastatic NSCLC [10–12]. Here, EGFR is linked to non-small cell lung carcinoma.