HLA-C and neoplasm: NKT cells have brilliant features that make them very useful cells against tumors, including double function capability (the ability to use innate receptors and engineered receptors for activation) [12], MHC-independent cytotoxicity, success in the “Off-The-Shelf” process (the rate of capability for creating the new modified cells), as well as improved anti-tumor immunity in the anergy process [13].