AKT1 and central nervous system cancer: Studies have also reported that IL-13Rα2 stimulates human glioma cell growth and metastasis through the Src/PI3K/Akt/mTOR signaling pathway [38] Despite advances in the understanding of IL-13Rα2 biology in glioma tumors and clinical trials targeting this receptor for therapy, the regulation and prognostic significance of IL-13Rα2 expression in glioma is not well understood.