RT-PCR analysis showed that compared with the relative viral genome level at late stages of viral infection (6 h), the relative viral genome at the early stage of viral infection (1 h), which is assumed to be the viral genome entry level (27), was blocked to a level less than 10% by HSP70 inhibition (Fig. 3A), suggesting that HSP70 mainly participates in early viral entry step during GCRV infection (Fig. 3A). Here, HSPA1A is linked to viral infectious disease.