For mammalian viruses such as dengue virus, influenza A virus, herpes simplex virus, Zika virus, Ebola virus, hepatitis B virus, and hepatitis C virus, accumulating evidence has shown that HSP70 may participate in all stages of viral infection, including internalization of the virus particle into host cells, viral genome replication, gene expression, virion assembly, and release (10). The gene discussed is HSPA1A; the disease is viral infectious disease.