Moreover, compared with infection at 18°C, temperature switch treatment from 18°C to 28°C boosted the viral genome replication and HSP70 transcription 20-fold and 10-fold, respectively (Fig. 2F and G, blue dashed line versus blue solid line), while 28°C to 18°C switches significantly slowed the viral genome replication and the expression of HSP70 (red dashed line versus red solid line). Here, HSPA1A is linked to infection.