Focusing on patients with rheumatic immune diseases, a prospective study conducted by C.M.F. Gomes et al. compared the sensitivity of TST and IGRAs in diagnosing LTBI in arthritis patients treated with TNF-α antagonists and found that IGRAs could improve the diagnostic accuracy of LTBI compared with TST; T-SPOT.TB in particular had a higher positive rate (14). The gene discussed is TNF; the disease is arthritic joint disease.