Although the function of RHOT2 in cancer is still unclear, the expression of its paralog RHOT1 affects metastasis in a variety of tumors, including pancreatic cancer, gastric cancer, small cell lung cancer, etc. (Li et al., 2015; Peng et al., 2022; Zhang et al., 2021). This evidence concerns the gene RHOT1 and familial pancreatic carcinoma.