Differential AS events from IECs of acute colitis were enriched in Alzheimer’s disease, glucagon-signaling pathway, cyclic guanosine-3’,5’-monophosphate (cGMP)- protein kinase G (PKG)-signaling pathway, Human T-cell leukemia virus type 1 (HTLV-I) infection, calcium-signaling pathway, insulin secretion, and so on (Figure 3B). The gene discussed is INS; the disease is early-onset autosomal dominant Alzheimer disease.