TRAF1 and malignant colon neoplasm: BCL2/adenovirus E1B-interacting protein 2 is a mediator of antiapoptotic activity, and its increased expression can lead to a large number of cell death.23 Moreover, it has been reported that the expression of Traf1 is increased in colonic mucosa of IBD patients.24 The hypermethylation of Traf7 is associated with colon cancer.25 Tumor necrosis factor receptor-associated factor 7 participated in suppressing the hyperpermeability of endothelial cells in inflammatory response,26 which indicates Traf7 may be related to the epithelial barrier of IBD.