SAMD9L is frequently mutated and inactivated in hepatocellular carcinoma, leading to a decrease in its expression levels and an increase in cell proliferation through accelerated cell cycle progression.25 These studies show that SAMD9L plays an important role in human malignant tumors and other diseases, although its role in the occurrence and development of gastric cancer is unknown. The gene discussed is SAMD9L; the disease is cancer.