FOXP3 and colitis: Cancer development-related signaling pathways such as PI3K-AKT, Ras, Wnt, and TGF-beta were found enriched in the colitis tissue.46 In a recent study, it was shown that Wnt-β-catenin activation alters the Treg cell population in IBD and dysplastic progression via epigenetic and transcriptional changes of Foxp3-TCF-1 co-regulated genes.