Histone modifications have been shown to regulate genes that affect chronic inflammation.54 Since CD4+ T cells are playing a crucial role in the pathogenesis of autoimmune disorders like multiple sclerosis and CD55 and are believed to be one of the key regulators of intestinal inflammation,56 there have been several publications that investigated the epigenetic alterations in CD4+ T cells. This evidence concerns the gene CD4 and autoimmune disease.