APOE and Alzheimer disease: However it is now known that total circulating CRP does not inform and is not correlated with plasma born circulating mCRP levels which now are accepted to be the important biomarker, and a novel risk factor; in this regard, Gan et al. [29] recently confirmed that mCRP directly stimulated cellular AD pathogenesis using murine cortical APOE ε4‐knock‐in neurons.