The most recent studies have provided evidence linking vascular inflammation with neurological and cognitive decline associated with AD, and in this regard, Zhang et al. [43], found that intraperitoneal injection of mCRP into ApoE4 knock‐in mice, caused abnormal vascular development and increased T lymphocyte extravasation in a CD31‐dependent mechanism, resulting in increased cognitive deficit (Figure 5). The gene discussed is APOE; the disease is Alzheimer disease.