Later, Strang et al [52], showed that mCRP positive IHS staining was associated with AD‐positive regions in post‐mortem cortical brain specimens, and that incubation of pCRP with Aβ(42)‐peptide in vitro, led to the generation of mCRP‐specific inflammatory Aβ‐plaques (Figure 9), whilst cerebral expression of CRP correlated with Aβ1‐42 and serum amyloid P component (SAP) indicating neurodegenerative capacity in a transgenic murine amyloid precursor protein (APP)/presenilin‐1 (PS1) model [53]. This evidence concerns the gene APP and Alzheimer disease.