In vitro, in vivo, and human tissue co‐localization analyses have linked mCRP to neurovascular dysfunction, vascular activation resulting in increased permeability, and leakage, compromise of blood brain barrier function, buildup of toxic proteins including tau and beta amyloid (Aβ), association with and capacity to “manufacture” Aβ‐mCRP‐hybrid plaques, and, greater susceptibility to neurodegeneration and dementia. Here, MAPT is linked to dementia.