It has been shown in tumor cells that ROS promote the transport of HMGB1 from the nucleus to the cytoplasm, while cytoplasmic HMGB1 interacts with Beclin-1, which, in turn, is released from the Beclin-1/Bcl-2 complex and induces autophagy [38,40]. The gene discussed is HMGB1; the disease is neoplasm.