EWSR1 and desmoplastic small round cell tumor: Desmoplastic small round cell tumor (DSRCT) is an ultra-rare sarcoma characterized by the specific chromosomal translocation t(11:22)(p13;q12) that leads to the fusion of the transcriptional regulatory domain of EWSR1 to the DNA-binding domain of WT1, resulting in the oncogenic EWSR1::WT1 gene fusion (Gerald et al., 1991; Ladanyi and Gerald, 1994).