AKT1 and desmoplastic small round cell tumor: In addition, the combined treatment reduced the expression of p-ERK1/2 (also known as MAPK3/1) (Thr202/Tyr204) and p-AKT (Ser473), suggesting the inhibition of RAS-MAPK and PI3K-AKT pathways, which are usually upregulated in DSRCT tumors (Smith et al., 2022).