Angiopoietin like 4 (Angptl4) is an angiogenic factor and lipid metabolism regulator that has been characterized in cumulus cells and in cases of polycystic ovarian syndrome (PCOS) (Al-Edani et al., 2014; Chaemsaithong et al., 2013; Haddad et al., 2006; Jiang et al., 2022; Kremer et al., 2016; Nhan-Chang et al., 2010). Here, ANGPTL4 is linked to polycystic ovary syndrome.