Recent studies show that inhibition of gain‐of‐function of mutated PPM1D can increase radiosensitivity of DIPG tumors through restoring the activation of p53,156, 162 and targeting PPM1D would sensitize DIPG cells to the PARP inhibitor due to dual suppression of HR and SSBR.163. The gene discussed is TP53; the disease is diffuse intrinsic pontine glioma.