The levels of angiogenin, angiotensinogen, CRP, IgG, IL‐1β, IL‐6, kallikrein 5, LOX‐1, MIP‐1α, MMP‐2, MMP‐9, PAI‐I, renin, S100b, Tau, TNF‐α, t‐PA, VEGF‐a, and VE‐cadherin in arterial blood did not change significantly after PFO closure (Figure 3D and Table 4). This evidence concerns the gene REN and Patent foramen ovale.