The levels of angiogenin, angiotensinogen, CRP, IgG, IL‐1β, IL‐6, kallikrein 5, LOX‐1, MIP‐1α, MMP‐2, MMP‐9, PAI‐I, renin, S100b, Tau, TNF‐α, t‐PA, VEGF‐a, and VE‐cadherin in arterial blood did not change significantly after PFO closure (Figure 3D and Table 4). Here, IL1B is linked to Patent foramen ovale.