In this study, we focused on the top HSPA5 binding genes, NEAT1, LRP1, EGFR, and TGFB1. A previous study reported that the lncRNA of nuclear paraspeckle assembly transcript 1 (NEAT1) was upregulated in NAFLD [24], in addition, the down‐regulation of lncRNA‐NEAT1 alleviated NAFLD via the mTOR/S6K1-signaling pathway [14]. Here, LRP1 is linked to metabolic dysfunction-associated steatotic liver disease.