PRNP and sporadic Creutzfeldt-Jakob disease: Beyond sporadic CJD, PrP plaques, including florid plaques and other less common types of plaques, have been described in iCJD, kuru, and variant CJD in humans, or in bovine spongiform encephalopathy (BSE) and chronic wasting disease (CWD) in animals [13, 16, 30, 43, 72].