Examples include IL-15, a proinflammatory cytokine implicated in the pathophysiology of Alzheimer’s Disease and frontotemporal dementia30; CCL23, a chemokine involved in brain injury-induced neuroinflammation and progressive cognitive impairment31; TNF receptors 1 and 2 (TNFR 1 and 2)32; and CSF-1, a molecule critical for activation of cerebral microglia and strongly implicated in neurodegenerative disease33. This evidence concerns the gene CSF1 and early-onset autosomal dominant Alzheimer disease.