As a result of our univariate Cox analysis, we found that high mRNA expressions of EYA1 (HR = 2.362, 95%CI 1.726–3.231, and P < 0.001), and low mRNA expression of EYA3 (HR = 0.502, 95%CI 0.368–0.685, and P < 0.001) were related to shorter OS of ccRCC patients. Here, EYA1 is linked to nonpapillary renal cell carcinoma.