TGFB1 and cancer: Mesenchymal cancer cells, however, consistently produced higher amounts of EMT-promoting matrisome components, for example, fibrillar collagen types I and V, fibronectin, Fgf2, Tgfb family proteins such as Tgfb3 and Bmp2 as well as proteins involved in Tgfb signaling modulation, indicating a feed-forward loop with sustained local EMT signals (Fig. 5d, e).