Furthermore, in xenograft models, the enhanced tumor proliferation (Ki67) and decreased angiogenesis (CD31) due to MFAP5 overexpression in CAFs was also partially reverted by application of AMG487, along with increased Granzyme B+CD8+T cells infiltration (Figs. 5K, S7F–H). The gene discussed is GZMB; the disease is neoplasm.