METTL3 and non-small cell lung carcinoma: Together, these findings indicate that LINC00969 simultaneously interacts with EZH2 and METTL3, thereby regulating the expression of NLRP3 at the transcriptional and posttranscriptional levels, thus suppressing the NLRP3-induced classical pyroptosis pathway to promote gefitinib resistance in NSCLC.