The KD appeared to reduce liver weight/body weight ratio (Supplementary Fig. 4d) and significantly suppressed tumor multiplicity and total tumor volume (Fig. 4b), reproducing the phenotype observed in the Scd2f/f;CC mice and validating the role of LTB4R2 in CTNNB1 and YAP1 activation and liver tumorigenesis in vivo. Here, CTNNB1 is linked to neoplasm.