We recently showed conditional ablation of stearoyl CoA desaturase 2 (Scd2) in Col1a1-expressing cells in Scd2f/f mice carrying Col1a1-Cre (Scd2f/f;Col1a1-Cre) attenuated HCC development initiated by diethyl nitrosamine (DEN) and promoted by Western alcohol diet (WAD)6. The gene discussed is SCD5; the disease is hepatocellular carcinoma.