Also, the study proposes that CD8+ T cells in the blood of BD patients are chronically immune activated, leave the circulating blood, and migrate to peripheral tissues, including brain regions, and that reduced WM integrity in the corpus callosum and left supra-radial corona is associated with reduced end CD8+ CD28- and CD8+ IFN-γ+ populations [65]. This evidence concerns the gene IFNG and Behcet disease.