Rab10 hyperphosphorylation at T73 in human AD hippocampus was shown to be mediated by the serine/threonine protein kinase, leucine-rich repeat kinase 2 (LRRK2), leading to the aberrant membrane and vesicle trafficking and progression of neurodegeneration (Yan et al., 2018). This evidence concerns the gene LRRK2 and Alzheimer disease.