NFE2L2 and hepatocellular carcinoma: 8-OHdG levels were found to be significantlyincreased in chronic hepatitis C patients with hepatocellular carcinoma(HCC) compared to chronic hepatitis C patients without HCC.124 Both 8-OHdG and NRF2 expressions were foundto be significantly elevated in cancerous tissue compared to noncanceroustissue of HCC patients.125 Again, thesebiomarkers are indicative of oxidative stress in the cancer patientwhich is more likely the consequence rather than the cause of thetumor.