CLOCK and psychiatric disorder: The central circadian clock is locatedin the hypothalamus, which synchronizes information on environmentallight and dark signals to peripheral tissues to keep the body functioningin the same rhythm.180 A disruption ofcircadian rhythms is associated with various diseases, including neurodegenerativediseases, sleep, and psychiatric disorders.181,182 Recent studies have reported that gut microbiota are able to controlor be controlled by the circadian clock.