Furthermore, detection of lipocalin-2 expression level in fecal was performed to evaluate the induction of gut inflammation, Compared to WT-mice, a significantly decreased levels of IL-1β, IL-18, and fecal lipocalin-2 were detected in infected Casp1-/—mice (Fig 11E, 11F, and 11H), suggesting that Caspase-1-dependent inflammasome was markedly activated in WT-mice after SE infection, accompanied by stronger gut inflammation. This evidence concerns the gene IL18 and infection.