In addition, the Casp1-/—, IL-1β-/—, and IL-18-/—mice also succumbed to Salmonella infection more rapidly than wild-type (WT)-C57BL/6 mice, with markedly higher bacterial burdens in spleens, Peyer’s patches, and mesenteric lymph nodes [15]. This evidence concerns the gene IL18 and Salmonella Infections.