In our cohort of STIM1-TAM patients, flexor hallucis longus and subscapularis muscles were almost always affected, confirming the known pattern of muscle involvement and the usefulness of evaluating specific muscles that rarely are involved in the pathological process [14], in the differential diagnosis with many others muscle diseases (i.e., alpha dystroglycanopathies, calpainopathy, TPM2-related and RYR1-related myopathies, among the others). Here, STIM1 is linked to neuromuscular disease caused by qualitative or quantitative defects of alpha-dystroglycan.