For example, PICALM (Moreau et al, 2014) is involved in autophagy and clearance of Aβ, BECN1 (Rocchi et al, 2017) aids autophagy and APP processing, AKT1 is important for ROS production (Ahmad et al, 2017), AXL has recently been linked to AD due to its direct role in promoting Aβ plaque development through microglial phagocytosis (Huang et al, 2021b), and RICTOR (Lee et al, 2017) is important for protecting the cells from Aβ‐induced toxicity. The gene discussed is PICALM; the disease is Alzheimer disease.