When we compared DE genes of Aβ + apoE2 + FH and Aβ + apoE4 + FH samples to all samples we observed upregulation of genes (LMTK2, ATP1A1, FLOT1 and DNAJC5; Tiwari et al, 2015; Petrushanko et al, 2016; Abdullah et al, 2019; Bencze et al, 2019) that when downregulated could potentially promote AD pathogenesis (Fig 5B–D, Table 1, Appendix Table S5 and Dataset EV2). The gene discussed is APOE; the disease is Alzheimer disease.