We used cortical brain biopsy samples obtained from apoE genotyped iNPH patients as a tool to understand the Aβ induced neuroinflammation in vivo, as 50% of iNPH patients develop lesions of Aβ plaques leading eventually to development of AD (Luikku et al, 2019; Appendix Table S1, patient data). Here, APOE is linked to Alzheimer disease.