TNF and non-small cell lung carcinoma: Alemán et al. (2002) examined leptin serum levels in non-small cell lung cancer patients and found that leptin levels were less than in healthy individuals. Besides, they found that the levels of CRP, ferritin, TNF-a, IL-6 are inversely proportional to the leptin level (Alemán et al., 2002). There are studies showing that high leptin or leptin receptor levels in primary ovarian tumors are associated with a poor prognosis (Uddin et al., 2009; Diaz, Karlan & Li, 2013).