An increase in T4 and TBG, as well as an increase in acute phase proteins, can be caused by acute liver disease and primary biliary cirrhosis. A meta-analysis reported that decreased free T3 (fT3) and free T4 (fT4) levels were significantly associated with a higher risk of liver cirrhosis, whereas increasing TSH levels were positively associated with the risk of liver cirrhosis [8]. This evidence concerns the gene SERPINA7 and cirrhosis of liver.