A Mendelian randomization study using participant data from 16 prospective cohorts showed that cystatin C was not causally associated with CVD (RR: 1.00; 95% CI: 0.82, 1.22) and stroke (RR: 0.82; 95% CI: 0.57, 1.18) [9]. This evidence concerns the gene CST3 and stroke disorder.