Higher cystatin C levels were significantly associated with stroke risk in the overall population (B = 4.205, 95% CI = 3.180–5.230, p < .001), in men (B = 1.872, 95% CI = 0.465–3.278, p = .009) and in women (B = 4.029, 95% CI = 2.252–5.806, p < .001). This evidence concerns the gene CST3 and stroke disorder.