Table 3 shows that the association between serum B2M level and stroke risk was significant in the overall population (B = 0.726, 95% CI = 0.506–0.947, p < .001), men (B = 0.289, 95% CI = 0.001–0.576, p = .049) and women (B = 0.928, 95% CI = 0.569–1.287, p < .001). This evidence concerns the gene B2M and stroke disorder.