In this study, our network pharmacology findings of correlative target genes in genistein and CRC by targeting autophagy suggested that 10 core genes had the highest degree scores, this included microtubule-associated protein tau (MAPT), ESR1, alpha-synuclein (SNCA), matrix metallopeptidase 9 (MMP9), EGFR, cyclin-dependent kinase 1 (CDK1), amyloid precursor protein (APP), CDK5, insulin-like growth factor binding protein 3 (IGFBP3), and glycogen synthase kinase 3beta (GSK3B). Here, IGFBP3 is linked to colorectal carcinoma.