To explore the possible effect of oridonin on the progression of atherosclerosis in vivo, ApoE−/− mice fed with a high-fat diet were intraperitoneally injected with 10 mg/kg (AS + Ori 10 mg/kg group) or 20 mg/kg oridonin (AS + Ori 20 mg/kg group) or normal saline (AS group) every day for 12 weeks. Here, APOE is linked to atherosclerosis.