Sixty-seven patients were diagnosed with CGD, 73 with VEO-IBD, 48 with SCID, and 42 with other types of IEI, including Wiskott–Aldrich syndrome (WAS), leukocyte adhesion deficiency (LAD), and hyper-IgM (HIgM) syndrome. This evidence concerns the gene CD40LG and hyper-IgM syndrome type 1.