MAPT and early-onset autosomal dominant Alzheimer disease: To assess if tau seeding activities correspond with severity of Aβ pathology, we evaluated the correlation of 3R/4R tau seeding activities with Thal phases [57] and Consortium to Establish a Registry for Alzheimer Disease (CERAD) scores [44] as indicators of Aβ deposition and the abundance of neuritic amyloid plaques, respectively.