NCKAP1 and amyotrophic lateral sclerosis: Despite of the abovementioned limitation, we report for the first time that defective phagocytic function in microglia-like cells of rapidly progressing sALS patients is involved in the reduced expression of NCKAP1. NCKAP1 reduction in microglia may interfere with the engulfment step of phagocytosis and induce immune vigilance, leading to rapid progression in ALS.