In qRT‐PCR analysis, microglia signature genes (P2RY12, OLFML3, TGFBR1, GPR34, MERTK, HEXB, CSF1R, and TMEM119) [40] were upregulated in ALS(S)-iMGs and ALS(R)-iMGs versus individual monocytes, which two-group expression level was not significantly different (Fig. 3b). This evidence concerns the gene HEXB and amyotrophic lateral sclerosis.