To gain the specific role of XIAP on autophagy regulation in AML, we used birinapant or XIAP siRNA to treat AML cells and found that both birinapant and XIAP siRNA upregulated the levels of microtubule‐associated protein 1 light chain 3 (LC3‐II), a well‐established marker of autophagy, and consequently, downregulated the expression of SQSTM1/p62, an endogenous autophagy substrate, suggesting that XIAP may act as an inhibitor of autophagy and its inhibition can enhance autophagy in AML (Figure 4A, and Figure S4A). The gene discussed is XIAP; the disease is acute myeloid leukemia.