Zhang et al. [59] found that exosomes derived from RBPJ overexpressing macrophages could secrete hsa_circ_0004658 to suppress the proliferation and induce apoptosis of HCC cells by competing with junctional adhesion molecule 3 (JAM3) mRNA to target miR-499b-5p. This evidence concerns the gene JAM3 and hepatocellular carcinoma.