Lyu et al. [43] demonstrated that hsa_circ_0070396 was upregulated in plasma-derived exosomes; moreover, the diagnostic power of exosomal circ_0070396 was better than that of AFP, with AUCs of 0.8574 and 0.7741, respectively, for distinguishing HCC from healthy donors and CHB patients, while AUCs of AFP were 0.781 and 0.7442. Here, AFP is linked to hepatocellular carcinoma.