Kaplan‒Meier survival analysis showed that higher RNF8 expression was associated with worse overall survival (OS,P=0.0041), worse disease-specific survival (DSS,P=0.0037), worse progression-free survival (PFS,P=0.0099) and worse relapse-free survival (DFS,P=0.0057) in liver cancer patients (Figure 2). Here, RNF8 is linked to liver cancer.