ASTN2 and Anxiety: CNVs impacting NRXN1 (with ADHD, OCD, anxiety traits, ASD, executive function and learning problems), ASTN2 in male (with ADHD, anxiety and seizure) and CHD2 (ADHD, learning problems, epilepsy and hearing problems) were examples of non-recurrent clinically significant CNVs associated with phenotypes (Fig. 1C; Table 2; Supplementary Material, Table S3).