PRRX1 and craniosynostosis: Initial analysis of GS data from 9 parent-child trios with previously undiagnosed syndromic/multisuture craniosynostosis (Supplemental Table 1) revealed a de novo single-nucleotide deletion of PRRX1 (NM_022716.4:c.52del, predicting a frameshift p.(Arg18Alafs∗23)), in a child (family 2, II-1; Table 1) presenting with bicoronal synostosis.