Another study mining data of LUAD patients from the Genomic Data Commons (GDC) Data Portal indicated that BRIP1 might regulate fibroblast growth factor 22 and affect MAPK as well as Rap 1 signalling pathways in all tumor stages of LUAD, and a high level of BRIP1 showed boundary significance on OS [26], in consistence with our results. This evidence concerns the gene FGF22 and neoplasm.