MMP9 and neoplasm: Wang et al., reported in previous works that the activity of certain proteases, like the matrix 2 metalloproteinase 2 (MMP-2) and the matrix metallopeptidase 9 (MMP-9) are related to the degradation of the ECM promoting tumor cell migration, invasion and metastasis, a phenomenon that has also been reported in other types of cancers (Bergers et al., 2000; Ahn and Brown, 2008; Gialeli et al., 2011; Wang et al., 2012; Mehner et al., 2014; Joseph et al., 2020, please be referred to Table 2 for more examples including their references).