Overexpression of the NHE1 has been reported in certain types of cancer cells, such as colorectal cancer and breast cancer cells where it contributes to proton efflux and regulates the cytosolic pH of the tumor cells (Lopez-Charcas et al., 2022), the pharmacological inhibition or gene knockout drives a reduction in the efflux rate, compromising the regulation of internal pH (Lopez-Charcas et al., 2022). The gene discussed is SLC9A1; the disease is colorectal cancer.