These enzymes, such as matrix metalloproteinases (MMPs), can be expressed by tumoral cells in the tumor itself (Bergers et al., 2000; Yang et al., 2004; Vihinen et al., 2005; Kessenbrock et al., 2010; Gialeli et al., 2011; Mehner et al., 2014; Yousef et al., 2014), It has been observed that MMP9, is one of the most important proteolytic enzymes in ECM remodeling in various types of cancers (Bergers et al., 2000; Huang et al., 2002; Yang et al., 2004; Ahn and Brown, 2008; Yousef et al., 2014; Joseph et al., 2020). The gene discussed is MMP9; the disease is cancer.