HVCN1 and breast carcinoma: Recovery experiments were also performed, with no changes observed for MCF-10A cells, a slight recuperation of cell viability in MCF-7 cells but a compromised cell viability in MDA-MB-231 cells, suggesting that Hv1 in these tumorigenic breast-cancer lines does influence their cell viability related to the cytosolic proton extrusion (Ventura et al., 2020).