Currently, there has been an increasing number of studies that report that the Hv1 proton channel has a key role in proton extrusion in tumor cells, relating their overexpression in some cases to tumor malignancy (Wang et al., 2011; Wang et al., 2012; Wang et al., 2013a; Asuaje et al., 2017). Here, HVCN1 is linked to neoplasm.